Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …

The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Amyloid-like aggregates of the microtubule-associated protein Tau are associated with
several neurodegenerative disorders including Alzheimer's disease. The existence of …

Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to
large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and …

The most common inherited cause of two genetically and clinico-pathologically overlapping
neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal …

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is a hexanucleotide expansion in the chromosome 9 open reading frame 72 …

Expansion of a (G 4 C 2) n repeat in C9orf72 causes amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD), but the link of the five repeat-encoded dipeptide repeat …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact
causative mechanisms are still under intense investigation. Several lines of evidence …

ER stress signaling is linked to the pathophysiological and clinical disease manifestations in
amyotrophic lateral sclerosis (ALS). Here, we have investigated ER stress-induced adaptive …

Our review seeks to elucidate the current state-of-the-art in studies of 70-kilodalton-weighed
heat shock proteins (Hsp70) in neurodegenerative diseases (NDs). The family has already …