Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?

J Hou, M Karin, B Sun - Nature reviews Clinical oncology, 2021 - nature.com
The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …

Immune checkpoint inhibitor-associated colitis: from mechanism to management

L Tang, J Wang, N Lin, Y Zhou, W He, J Liu… - Frontiers in …, 2021 - frontiersin.org
Immune checkpoint inhibitors (ICIs), as one of the innovative types of immunotherapies,
including programmed cell death-1 (PD-1), programmed cell death-ligand 1 (PD-L1), and …

Science-driven nutritional interventions for the prevention and treatment of cancer

L Montégut, R de Cabo, L Zitvogel, G Kroemer - Cancer discovery, 2022 - AACR
In population studies, dietary patterns clearly influence the development, progression, and
therapeutic response of cancers. Nonetheless, interventional dietary trials have had …

Neutrophil to Lymphocyte ratio as a predictor for immune-related adverse events in cancer patients treated with immune checkpoint inhibitors: a systematic review and …

W Zhang, Y Tan, Y Li, J Liu - Frontiers in Immunology, 2023 - frontiersin.org
Background The use of immune checkpoint inhibitors (ICIs) in cancer treatment has led to an
increase in immune-related adverse events (irAEs), which can cause treatment …

Mechanisms of immune checkpoint inhibitor-mediated colitis

H Westdorp, MWD Sweep, MAJ Gorris… - Frontiers in …, 2021 - frontiersin.org
Immune checkpoint inhibitors (ICIs) have provided tremendous clinical benefit in several
cancer types. However, systemic activation of the immune system also leads to several …

Cytokine changes during immune-related adverse events and corticosteroid treatment in melanoma patients receiving immune checkpoint inhibitors

K Tyan, J Baginska, M Brainard… - Cancer Immunology …, 2021 - Springer
Abstract Background Immune checkpoint inhibitors (ICIs) often cause immune-related
adverse events (irAEs), most of which are treated with corticosteroids despite evidence …

Vitamin D supplementation increases objective response rate and prolongs progression‐free time in patients with advanced melanoma undergoing anti–PD‐1 …

Ł Galus, M Michalak, M Lorenz, R Stoińska‐Swiniarek… - Cancer, 2023 - Wiley Online Library
Background Vitamin D3 is a prohormone with pleiotropic effects, including modulating the
functions of the immune system and may affect the effectiveness of anti–PD‐1 treatment in …

Stocking the toolbox—Using preclinical models to understand the development and treatment of immune checkpoint inhibitor‐induced immune‐related adverse …

ML Cina, J Venegas, A Young - Immunological Reviews, 2023 - Wiley Online Library
Cancer patients treated with immune checkpoint inhibitors (ICIs) are susceptible to a broad
and variable array of immune‐related adverse events (irAEs). With increasing clinical use of …

Fecal microbiota transplantation effectively cures a patient with severe bleeding immune checkpoint inhibitor-associated colitis and a short review

M Chen, M Liu, C Li, S Peng, Y Li, X Xu, M Sun… - Frontiers in …, 2022 - frontiersin.org
Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but
simultaneously led to the occurrence of immune-related adverse events. We report a case of …

Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies

A Gusev - Immunological Reviews, 2023 - Wiley Online Library
Cancer immunotherapy has revolutionized the treatment of advanced cancers and is quickly
becoming an option for early‐stage disease. By reactivating the host immune system …