Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

PURPOSE To develop recommendations for germline mutation testing for patients with
breast cancer. METHODS An ASCO–Society of Surgical Oncology (SSO) panel convened to …

Simple Summary The role of gender in oncology is an issue that is starting to be recognized
as being of extreme importance in the last few years. While breast cancer is commonly …

Recent advancements in next-generation sequencing have greatly expanded the use of
multi-gene panel testing for hereditary cancer risk. Although genetic testing helps guide …

Background Germline risk assessment is increasing as part of cancer care; however,
disparities in subsequent genetic counseling are unknown. Methods Pan‐cancer patients …

Germline mutations in checkpoint kinase 2 (CHEK2), a multiple cancer‐predisposing gene,
increase breast cancer (BC) risk; however, risk estimates differ substantially in published …

Identification of modifiable risk factors for breast cancer is critical for primary prevention of
the disease. The aim of this study was to evaluate how certain lifestyle variables modify the …

Genomic medicine is expanding from a focus on diagnosis at the patient level to prevention
at the population level given the ongoing under-ascertainment of high-risk and actionable …

Missense mutations that disrupt the RING domain of the tumor suppressor gene BRCA1
lead to increased risk of breast and ovarian cancer. The BRCA1 RING domain is a ubiquitin …

Background Studies evaluating role of BRCA mutations on the survival outcomes in breast
cancer (BC) patients have given confounding results and hence, in this meta-analysis, we …