For decades, budding yeast, a single-cellular eukaryote, has provided remarkable insights
into human biology. Yeast and humans share several thousand genes despite …

Gene families evolve by the processes of speciation (creating orthologs), gene duplication
(paralogs), and horizontal gene transfer (xenologs), in addition to sequence divergence and …

There is great interest in being able to spread beneficial traits throughout wild populations in
ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element …

Although transplantation of single genes in yeast plays a key role in elucidating gene
functionality in metazoans, technical challenges hamper humanization of full pathways and …

The capacity of haem to transfer electrons, bind diatomic gases, and catalyse various
biochemical reactions makes it one of the essential biomolecules on Earth and one that was …

Defects in hydroxymethylbilane synthase (HMBS) can cause acute intermittent porphyria
(AIP), an acute neurological disease. Although sequencing-based diagnosis can be …

The mechanisms initiating apoptotic programmed cell death in diverse eukaryotes are very
similar. Basically, the mitochondrial permeability transition activates apoptotic proteases …

Despite over a billion years of evolutionary divergence, several thousand human genes
possess clearly identifiable orthologs in yeast, and many have undergone lineage-specific …

Prediction of orthologs is an important bioinformatics pursuit that is frequently used for
inferring protein function and evolutionary analyses. The InParanoid database is a well …

The identification of orthologs—genes in different species which descended from the same
gene in their last common ancestor—is a prerequisite for many analyses in comparative …