15 years of GWAS discovery: Realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Advances and applications of polygenic scores for coronary artery disease
Polygenic scores quantify inherited risk by integrating information from many common sites
of DNA variation into a single number. Rapid increases in the scale of genetic association …
of DNA variation into a single number. Rapid increases in the scale of genetic association …
[HTML][HTML] Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization
ACF Lewis, EF Perez, AER Prince, HR Flaxman… - Genome Medicine, 2022 - Springer
Background Polygenic risk scores (PRS), which offer information about genomic risk for
common diseases, have been proposed for clinical implementation. The ways in which PRS …
common diseases, have been proposed for clinical implementation. The ways in which PRS …
[HTML][HTML] A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …
onset—remains an important public health need. Prior studies have developed genome …
Laboratory perspectives in the development of polygenic risk scores for disease: A points to consider statement of the American College of Medical Genetics and …
HV Reddi, H Wand, B Funke, MT Zimmermann… - Genetics in …, 2023 - Elsevier
Disclaimer: This Points to Consider document is designed primarily as an educational
resource for clinical laboratory geneticists to help them provide quality clinical laboratory …
resource for clinical laboratory geneticists to help them provide quality clinical laboratory …
Primary care physician use of patient race and polygenic risk scores in medical decision-making
BJ Kerman, CA Brunette, EJ Harris, AA Antwi… - Genetics in …, 2023 - Elsevier
Purpose The use of patient race in medicine is controversial for its potential either to
exacerbate or address health disparities. Polygenic risk scores (PRSs) have emerged as a …
exacerbate or address health disparities. Polygenic risk scores (PRSs) have emerged as a …
[HTML][HTML] Prognostic evaluation of polygenic risk score underlying pan-cancer analysis: evidence from two large-scale cohorts
J Xin, X Jiang, H Li, S Chen, Z Zhang, M Wang, D Gu… - …, 2023 - thelancet.com
Background Polygenic risk score (PRS) has been demonstrated to be effective in identifying
individuals at high risk of developing cancer, but its prognostic value remains unclear …
individuals at high risk of developing cancer, but its prognostic value remains unclear …
Polygenic risk scores for dyslipidemia and atherosclerotic cardiovascular disease: Progress toward clinical implementation
Recent discoveries from the past 15 years of human genetic association studies have
provided new insights into the common genetic basis of coronary artery disease and its risk …
provided new insights into the common genetic basis of coronary artery disease and its risk …
Cardiovascular disease risk assessment using traditional risk factors and polygenic risk scores in the million veteran program
Importance Primary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on
risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve …
risk stratification. Genome-wide polygenic risk scores (PRSs) are proposed to improve …
Polygenic score informed by genome-wide association studies of multiple ancestries and related traits improves risk prediction for coronary artery disease
Accurate stratification of coronary artery disease (CAD) risk remains a critical need. A new
polygenic score (GPSMult) incorporates CAD genome-wide association data across five …
polygenic score (GPSMult) incorporates CAD genome-wide association data across five …