siRNA versus miRNA as therapeutics for gene silencing
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …
Regulatory aspects on nanomedicines
Nanomedicines have been in the forefront of pharmaceutical research in the last decades,
creating new challenges for research community, industry, and regulators. There is a strong …
creating new challenges for research community, industry, and regulators. There is a strong …
Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo
P Zhupanyn, A Ewe, T Büch, A Malek… - Journal of Controlled …, 2020 - Elsevier
Extracellular vesicles (ECVs) are secreted cell-derived membrane particles involved in
intercellular signaling and cell-cell communication. By transporting various bio …
intercellular signaling and cell-cell communication. By transporting various bio …
Editorial focus: understanding off-target effects as the key to successful RNAi therapy
R Bartoszewski, AF Sikorski - Cellular & molecular biology letters, 2019 - Springer
With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy
Small interfering RNA (siRNA) is a relatively novel nucleic acid-based therapy to treat
diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have …
diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have …
[HTML][HTML] Next-generation clinical trials: novel strategies to address the challenge of tumor molecular heterogeneity
DVT Catenacci - Molecular oncology, 2015 - Elsevier
The promise of 'personalized cancer care'with therapies toward specific molecular
aberrations has potential to improve outcomes. However, there is recognized heterogeneity …
aberrations has potential to improve outcomes. However, there is recognized heterogeneity …
Poly (vinyl pyrrolidone) derivatives as PEG alternatives for stealth, non-toxic and less immunogenic siRNA-containing lipoplex delivery
The recent approval of Onpattro® and COVID-19 vaccines has highlighted the value of lipid
nanoparticles (LNPs) for the delivery of genetic material. If it is known that PEGylation is …
nanoparticles (LNPs) for the delivery of genetic material. If it is known that PEGylation is …
Visualization of self-delivering hydrophobically modified siRNA cellular internalization
Abstract siRNAs are a new class of therapeutic modalities with promising clinical efficacy
that requires modification or formulation for delivery to the tissue and cell of interest …
that requires modification or formulation for delivery to the tissue and cell of interest …
A comprehensive review of small interfering RNAs (siRNAs): mechanism, therapeutic targets, and delivery strategies for cancer therapy
J Zhang, B Chen, C Gan, H Sun, J Zhang… - International Journal of …, 2023 - Taylor & Francis
Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising
strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized …
strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized …
Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics
F Movahedi, RG Hu, DL Becker, C Xu - … : Nanotechnology, Biology and …, 2015 - Elsevier
Nucleic acid therapeutics (NATs) are valuable tools in the modulation of gene expression in
a highly specific manner. So far, NATs have been actively pursued in both pre-clinical and …
a highly specific manner. So far, NATs have been actively pursued in both pre-clinical and …