Over the past few decades, biopredictive dissolution coupled with physiologically based
biopharmaceutics modeling (PBBM) has gained significance due to its ability to predict in …

The pharmaceutical industry has faced significant changes in recent years, primarily
influenced by regulatory standards, market competition, and the need to accelerate drug …

Biorelevant dissolution and its concept have been widely accepted and further developed to
meaningfully predict the bioperformance of oral drug products. Biorelevant methodologies …

COMPASS is a novel tool for predicting the in vivo similarity of immediate-release oral
dosage forms. It bridges the gap between straightforward but purely mathematical f2 factor …

In this work, the ability of the artificial stomach and duodenum (ASD) model to predict
bioavailability in rats was investigated using a poorly soluble model compound, BI-639667 …