Coronavirus infection and cholesterol metabolism

J Dai, H Wang, Y Liao, L Tan, Y Sun, C Song… - Frontiers in …, 2022 - frontiersin.org
Host cholesterol metabolism remodeling is significantly associated with the spread of human
pathogenic coronaviruses, suggesting virus-host relationships could be affected by …

Structures of the σ2 receptor enable docking for bioactive ligand discovery

A Alon, J Lyu, JM Braz, TA Tummino, V Craik… - Nature, 2021 - nature.com
The σ2 receptor has attracted intense interest in cancer imaging, psychiatric disease,
neuropathic pain,–and other areas of biology,. Here we determined the crystal structure of …

Advances in technologies for highly active omega-3 fatty acids from krill oil: Clinical applications

A Colletti, G Cravotto, V Citi, A Martelli, L Testai… - Marine Drugs, 2021 - mdpi.com
Euphausia superba, commonly known as krill, is a small marine crustacean from the
Antarctic Ocean that plays an important role in the marine ecosystem, serving as feed for …

[图书][B] Liquid chromatography: applications

S Fanali, PR Haddad, C Poole, ML Riekkola - 2017 - books.google.com
Liquid Chromatography: Applications, Second Edition, is a single source of authoritative
information on all aspects of the practice of modern liquid chromatography. It gives those …

[HTML][HTML] Knockouts of CYP51A1, DHCR24, or SC5D from cholesterol synthesis reveal pathways modulated by sterol intermediates

C Skubic, H Trček, P Nassib, T Kreft, A Walakira… - Iscience, 2024 - cell.com
Sterols from cholesterol synthesis are crucial for cholesterol production, but also have
individual roles difficult to assess in vivo due to essentiality of cholesterol. We developed …

COVID-19 and cholesterol biosynthesis: Towards innovative decision support systems

E Kočar, S Katz, Ž Pušnik, P Bogovič, G Turel, C Skubic… - Iscience, 2023 - cell.com
With COVID-19 becoming endemic, there is a continuing need to find biomarkers
characterizing the disease and aiding in patient stratification. We studied the relation …

Histone deacetylase HDAC3 regulates ergosterol production for oxidative stress tolerance in the entomopathogenic and endophytic fungus Metarhizium robertsii

S Liu, X Wang, X Tang, W Fang - Msystems, 2024 - journals.asm.org
Oxidative stress is encountered by fungi in almost all niches, resulting in fungal
degeneration or even death. Fungal tolerance to oxidative stress has been extensively …

Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key …

M Feng, Y Jin, S Yang, AM Joachim, Y Ning… - International Journal for …, 2022 - Elsevier
Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites.
Current chemotherapeutic options against the deadly disease have significant limitations …

Aziridination-Assisted Mass Spectrometry of Nonpolar Sterol Lipids with Isomeric Resolution

E Hirtzel, M Edwards, D Freitas, Z Liu… - Journal of the …, 2023 - ACS Publications
Characterization of nonpolar lipids is crucial due to their essential biological functions and
ability to exist in various isomeric forms. In this study, we introduce the N–H aziridination …

Highly active cranberry's polyphenolic fraction: new advances in processing and clinical applications

A Colletti, L Sangiorgio, A Martelli, L Testai, AFG Cicero… - Nutrients, 2021 - mdpi.com
Cranberry is a fruit originally from New England and currently growing throughout the east
and northeast parts of the USA and Canada. The supplementation of cranberry extracts as …