Programmed death ligand 1 (PD-L1, also known as B7 homolog 1 or CD274) is a major
obstacle to antitumor immunity because it tolerizes/anergizes tumor-reactive T cells by …

Tolerance against self-antigens is regulated by a variety of cell types with immunoregulatory
properties, such as CD1d-restricted invariant natural killer T (iNKT) cells. In many …

Messenger RNA encoding tumor antigens has the potential to evoke effective antitumor
immunity. This study reports on a nanoparticle platform, named mRNA Galsomes, that …

Intratumoral cytotoxic T lymphocytes are critical for controlling tumor recurrence, and
programmed death-1 (PD-1) is a recognized marker of T-cell dysfunction. We analyzed this …

Invariant natural killer T (iNKT) cells become activated during a wide variety of infections.
This includes organisms lacking cognate CD1d-binding glycolipid antigens recognized by …

The role of invariant natural killer T (iNKT) cells in antitumor immunity has been studied
extensively, and clinical trials in patients with advanced cancer have revealed a prolonged …

Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in
the liver and recognize lipids presented on the MHC-like molecule CD1d. Although capable …

Simple Summary All conventional major histocompatibility complex (MHC)-restricted T cells
transiently express immune checkpoint/inhibitory receptors (ICRs) following activation as a …

Invariant or Type 1 NKT cells (iNKT cells) are a unique population of lymphocytes that share
characteristics of T cells and natural killer (NK) cells. Various studies have shown that …

CD160 and BTLA both bind to herpes virus entry mediator. Although a negative regulatory
function of BTLA in natural killer T (NKT) cell activation has been reported, whether CD160 …