TMEM106B, encoding a lysosome membrane protein, has been recently associated with
brain aging, hypomyelinating leukodystrophy and multiple neurodegenerative diseases …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Background Mutations of the gene TMEM106B are risk factors for diverse
neurodegenerative diseases. Previous understanding of the underlying mechanism focused …

Lysosomes have fundamental physiological roles and have previously been implicated in
Parkinson's disease,,,–. However, how extracellular growth factors communicate with …

Several studies using cryogenic electron microscopy (cryo-EM) techniques recently reported
the isolation and characterization of novel protein filaments, composed of a C-terminal …

Background It has been well established that the TMEM106B gene rs1990622 variant was a
frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the …

Since the initial identification of TMEM106B as a risk factor for frontotemporal lobar
degeneration (FTLD), multiple genetic studies have found TMEM106B variants to modulate …

TMEM106B, a lysosomal transmembrane protein, has been closely associated with brain
health. Recently, an intriguing link between TMEM106B and brain inflammation has been …

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar
degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM …

TMEM106B, a gene encoding a lysosome membrane protein, is tightly associated with brain
aging, hypomyelinating leukodystrophy, and multiple neurodegenerative diseases …