The α-synuclein origin and connectome model (SOC Model) of Parkinson's disease: explaining motor asymmetry, non-motor phenotypes, and cognitive decline
P Borghammer - Journal of Parkinson's disease, 2021 - content.iospress.com
A new model of Parkinson's disease (PD) pathogenesis is proposed, the α-Synuclein Origin
site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology …
site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology …
[HTML][HTML] Animal models of brain-first and body-first Parkinson's disease
N Van Den Berge, A Ulusoy - Neurobiology of disease, 2022 - Elsevier
Alpha-synuclein aggregates are the hallmark pathology of Parkinson's disease, which can
propagate in a stereotypical pattern along the brain-body axis. Parkinson's disease patients …
propagate in a stereotypical pattern along the brain-body axis. Parkinson's disease patients …
Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study
J Horsager, KB Andersen, K Knudsen, C Skjærbæk… - Brain, 2020 - academic.oup.com
Parkinson's disease is characterized by the presence of abnormal, intraneuronal α-
synuclein aggregates, which may propagate from cell-to-cell in a prion-like manner …
synuclein aggregates, which may propagate from cell-to-cell in a prion-like manner …
CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology
Parkinson's disease is characterized by the gradual appearance of intraneuronal inclusions
that are primarily composed of misfolded α-synuclein protein, leading to cytotoxicity and …
that are primarily composed of misfolded α-synuclein protein, leading to cytotoxicity and …
Structural and functional insights into α-synuclein fibril polymorphism
Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …
Brain regions susceptible to alpha-synuclein spreading
The spreading of misfolded alpha-synuclein (α-syn) protein has been observed in animal
models of Parkinson's disease (PD) and other α-synucleinopathies that mimic human PD …
models of Parkinson's disease (PD) and other α-synucleinopathies that mimic human PD …
Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns
Parkinson's disease is a progressive neurodegenerative disorder characterized by the
intracellular accumulation of insoluble alpha-synuclein aggregates into Lewy bodies and …
intracellular accumulation of insoluble alpha-synuclein aggregates into Lewy bodies and …
A phase II study to evaluate the safety and efficacy of prasinezumab in early Parkinson's disease (PASADENA): rationale, design, and baseline data
Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical
progression nor target alpha-synuclein, a key protein associated with the disease. Objective …
progression nor target alpha-synuclein, a key protein associated with the disease. Objective …
[HTML][HTML] PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats
MB Thomsen, SA Ferreira, AC Schacht… - Neurobiology of …, 2021 - Elsevier
Abstract Alpha-synuclein (a-syn) can aggregate and form toxic oligomers and insoluble
fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies are a …
fibrils which are the main component of Lewy bodies. Intra-neuronal Lewy bodies are a …
Treadmill exercise reduces α-synuclein spreading via PPARα
This study underlines the importance of treadmill exercise in reducing α-synuclein (α-syn)
spreading in the A53T brain and protecting nigral dopaminergic neurons. Preformed α-syn …
spreading in the A53T brain and protecting nigral dopaminergic neurons. Preformed α-syn …