Publisher Summary The chapter describes the understanding of the physics and physical
chemistry of sickle cell hemoglobin polymerization in solutions and in red cells. The …

Two main subjects of erythrocyte rheology, deformation and aggregation, are discussed in
detail, on the basis of biochemical structure. The close relationship between the life span (or …

Severe malaria by Plasmodium falciparum is a potentially fatal disease, frequently
unresponsive to even the most aggressive treatments. Host organ failure is associated with …

Whole cell deformability of red cells was measured as a continuous function of suspending
medium osmolality using the ektacytometer, a laser-diffraction viscometer. Study of normal …

Using a laser diffraction technique, we have studied factors that influence the deformability
of erythrocytes. Variations in suspending medium osmolality and applied shear stress were …

Malaria resulting from Plasmodium falciparum infection is a major cause of human suffering
and mortality. Red blood cell (RBC) deformability plays a major role in the pathogenesis of …

To further define the conditions for forming spectrin-hemoglobin cross-linking in human
erythrocyte membranes and to examine its possible effects on membrane function, we …

A longitudinal study of the red blood cell (RBC) deformability, percent of dense erythrocytes,
and hematologic parameters has been conducted during 117 painful crises affecting 36 …

Erythrocyte membrane mechanical function is regulated by the spectrin-based membrane
skeleton composed of α-and β-spectrin, actin, protein 4.1 R (4.1 R), and adducin. Post …

The amount of oxygen transported by unit volume of blood depends on the partial pressure
of oxygen in the blood, on the number of red cells per unit volume, on the amount of …