Basement membranes are formed from condensed networks of extracellular matrix (ECM)
proteins. These structures underlie all epithelial, mesothelial and endothelial sheets and …

The direct detection of drug-protein interactions in living cells is a major challenge in drug
discovery research. Recently, we introduced an approach termed thermal proteome profiling …

Data processing, management and visualization are central and critical components of a
state of the art high-throughput mass spectrometry (MS)-based proteomics experiment, and …

Homozygous loss of SMN1 causes spinal muscular atrophy (SMA), the most common and
devastating childhood genetic motor-neuron disease. The copy gene SMN2 produces …

Polypeptides encoded by long noncoding RNAs (lncRNAs) are a novel class of functional
molecules. However, whether these hidden polypeptides participate in the TP53 pathway …

The original PRIDE Converter tool greatly simplified the process of submitting mass
spectrometry (MS)-based proteomics data to the PRIDE database. However, after much user …

Over 200 million people suffer from osteoporosis worldwide, one third of which will develop
osteoporotic bone fractures. Unfortunately, no effective cure exists. Mutations in plastin 3 …

Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of
SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) …

Fruit cracking is a serious problem in Litchi chinensis cv. Baitangying orchards, but few
advances have been made in understanding the molecular basis of cracking susceptibility …

A critical step during fertilization is the sperm acrosome reaction in which the acrosome
releases its contents allowing the spermatozoa to penetrate the egg investments. The sperm …