The human hepatitis B virus (HBV) is a small-enveloped DNA virus causing acute and
chronic hepatitis. Despite the existence of an effective prophylactic vaccine and the strong …

Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide,
since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular …

The focus of hepatitis B functional cure, defined as sustained loss of hepatitis B virus (HBV)
surface antigen (HBsAg) and HBV DNA from blood, is on eliminating or silencing the …

Objective Therapeutic strategies silencing and reducing the hepatitis B virus (HBV)
reservoir, the covalently closed circular DNA (cccDNA), have the potential to cure chronic …

Background & Aims HBeAg seroconversion during the natural history of chronic hepatitis B
(CHB) is associated with a strong drop in serum HBV DNA levels and a reduction of …

Chronic hepatitis B is a numerically important cause of cirrhosis and hepatocellular
carcinoma, despite an effective prophylactic vaccine and well-tolerated and effective oral …

Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is the key genomic form
responsible for viral persistence and virological relapse after treatment withdrawal. The …

There is no cure for the more than 270 million people chronically infected with HBV. Nucleos
(t) ide analogs (NUCs), the mainstay of anti-HBV treatment, block HBV reverse transcription …

Hepatitis B virus (HBV) infection remains a public health problem worldwide. Persistent HBV
infection relies on active transcription of the covalently closed circular DNA (cccDNA) in …

Cure from chronic HBV infection is rare with current therapies. Basic research has helped to
fundamentally improve our knowledge of the viral life cycle and virus-host interactions, and …