The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

The concentration of Ca 2+ in the endoplasmic reticulum (ER) is critically important for
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

Misfolded proteins compromise cellular homeostasis. This is especially problematic in the
endoplasmic reticulum (ER), which is a high-capacity protein-folding compartment and …

The folding of secretory proteins is a well-understood mechanism, based on decades of
research on endoplasmic reticulum (ER) chaperones. These chaperones interact with newly …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …

Objective DNAJC3, also known as P58IPK, is an Hsp40 family member that interacts with
and inhibits PKR-like ER-localized eIF2α kinase (PERK). Dnajc3 deficiency in mice causes …

To fulfill its role in protein biogenesis, the endoplasmic reticulum (ER) depends on the
Hsp70-type molecular chaperone BiP, which requires a constant ATP supply. However, the …

In mammalian cells, one‐third of all polypeptides are integrated into the membrane or
translocated into the lumen of the endoplasmic reticulum (ER) via the Sec61 channel. While …