Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Ion channels are transmembrane structures that allow the passage of ions across cell
membranes such as the plasma membrane or the membranes of various organelles like the …

Several superfamilies of plasma membrane channels which regulate transmembrane ion
flux have also been shown to regulate a multitude of cellular processes, including …

Human ether-a-go-go related gene (hERG) channel gating is associated with slow
activation, yet the mechanistic basis for this is unclear. Here, we examine the effects of …

Potassium ions have widespread roles in cellular homeostasis and activation as a
consequence of their large outward concentration gradient across the surface membrane …

Initially developed in the mid-1990s to examine the conformational changes of the canonical
Shaker voltage-gated potassium channel, functional site-directed fluorometry has since …

Positively charged amino acids respond to membrane potential changes to drive voltage
sensor movement in voltage-gated ion channels, but determining the displacements of …

Kv1. 2 is a prominent potassium channel subtype in the nervous system and serves as an
important structural template for investigation of ion channel function. However, Kv1. 2 …

The Kv1. 2 channel, with its high resolution crystal structure, provides an ideal model for
investigating conformational changes associated with channel gating, and fluorescent …

The open state of voltage-gated potassium (Kv) channels is associated with an increased
stability relative to the pre-open closed states and is reflected by a slowing of OFF gating …