Terminators or guardians? design, synthesis, and cytotoxicity profiling of chalcone-sulfonamide hybrids
With a “less is more” philosophy, a series of 15 chalcone-sulfonamide hybrids were
designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was …
designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was …
[HTML][HTML] Exploring heterocyclic scaffolds in carbonic anhydrase inhibition: a decade of structural and therapeutic insights
N Naeem, A Sadiq, GA Othman, HM Yassin… - RSC …, 2024 - pubs.rsc.org
Heterocyclic compounds represent a prominent class of molecules with diverse
pharmacological activities. Among their therapeutic applications, they have gained …
pharmacological activities. Among their therapeutic applications, they have gained …
Design, synthesis, and structure–activity studies of new rhodanine derivatives as carbonic anhydrase II, IX inhibitors
KK Chinchilli, R Akunuri, SM Ghouse… - Archiv der …, 2023 - Wiley Online Library
Rhodanine and its derivatives are an important class of heterocycles with diverse biological
properties, including anticancer, antibacterial, and anti‐mycobacterial activities. In the …
properties, including anticancer, antibacterial, and anti‐mycobacterial activities. In the …
Chemistry of heterocycles as carbonic anhydrase inhibitors: A pathway to novel research in medicinal chemistry review
Nowadays, the scientific community has focused on dealing with different kinds of diseases
by exploring the chemistry of various heterocycles as novel drugs. In this connection …
by exploring the chemistry of various heterocycles as novel drugs. In this connection …
Development of Novel Indole-3-sulfonamide-heteroaryl Hybrids as Carbonic Anhydrase Inhibitors: Design, Synthesis and in-vitro Screening
Background: Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyze the reversible hydration of
carbon dioxide to bicarbonate and a proton. Inhibition of isoforms IX and XII has induced …
carbon dioxide to bicarbonate and a proton. Inhibition of isoforms IX and XII has induced …
Parsing p-tolyloxy-1, 3, 4-oxadiazolepropanamides as 15-lipoxygenase inhibitors prop up by in vitro and in silico profiling including structure determination
In humans, tissue injury result in the production of an inflammatory response and
arachidonic acid released from the damaged membrane phospholipids is oxidized in two …
arachidonic acid released from the damaged membrane phospholipids is oxidized in two …
Efficient Protocol for Novel Hybrid Pyrimidines Synthesis: Antiproliferative Activity, DFT Analyses, and Molecular Docking Studies
IO Althobaiti, MSM Alserhani, WAA Arafa… - ACS …, 2023 - ACS Publications
An efficient, microwave/ultrasound-irradiated synthesis of novel chromenopyrimidines has
been established. 2-Amino-5-oxo-4-(thiophen-2-yl)-5, 6, 7, 8-tetrahydro-4 H-chromene-3 …
been established. 2-Amino-5-oxo-4-(thiophen-2-yl)-5, 6, 7, 8-tetrahydro-4 H-chromene-3 …
Design, synthesis and molecular docking study of novel 3-phenyl-β-alanine-based oxadiazole analogues as potent carbonic anhydrase II inhibitors
Carbonic anhydrase-II (CA-II) is strongly related with gastric, glaucoma, tumors, malignant
brain, renal and pancreatic carcinomas and is mainly involved in the regulation of the …
brain, renal and pancreatic carcinomas and is mainly involved in the regulation of the …