Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE …

SP Patil, IA Ayappa, SM Caples, RJ Kimoff… - Journal of Clinical …, 2019 - jcsm.aasm.org
Introduction: The purpose of this systematic review is to provide supporting evidence for the
clinical practice guideline for the treatment of obstructive sleep apnea (OSA) in adults using …

[HTML][HTML] CPAP for prevention of cardiovascular events in obstructive sleep apnea

RD McEvoy, NA Antic, E Heeley, Y Luo… - … England Journal of …, 2016 - Mass Medical Soc
Background Obstructive sleep apnea is associated with an increased risk of cardiovascular
events; whether treatment with continuous positive airway pressure (CPAP) prevents major …

Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Trends in CPAP adherence over twenty years of data collection: a flattened curve

BW Rotenberg, D Murariu… - Journal of Otolaryngology …, 2016 - journals.sagepub.com
Background Obstructive sleep apnea (OSA) is a common disorder, and continuous airway
positive pressure (CPAP) is considered to be the gold standard of therapy. CPAP however is …

Effect of positive airway pressure on cardiovascular outcomes in coronary artery disease patients with nonsleepy obstructive sleep apnea. The RICCADSA …

Y Peker, H Glantz, C Eulenburg… - American journal of …, 2016 - atsjournals.org
Rationale: Obstructive sleep apnea (OSA) is common in patients with coronary artery
disease (CAD), many of whom do not report daytime sleepiness. First-line treatment for …

Associations of obstructive sleep apnea with atrial fibrillation and continuous positive airway pressure treatment: a review

D Linz, RD McEvoy, MR Cowie, VK Somers… - JAMA …, 2018 - jamanetwork.com
Importance Obstructive sleep apnea (OSA) is the most common clinically significant
breathing abnormality during sleep. It is highly prevalent among patients with atrial …

Upper-airway stimulation for obstructive sleep apnea

PJ Strollo Jr, RJ Soose, JT Maurer… - … England Journal of …, 2014 - Mass Medical Soc
Background Obstructive sleep apnea is associated with considerable health risks. Although
continuous positive airway pressure (CPAP) can mitigate these risks, effectiveness can be …

Effect of liraglutide 3.0 mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial

A Blackman, GD Foster, G Zammit… - International journal of …, 2016 - nature.com
Background: Obesity is strongly associated with prevalence of obstructive sleep apnea
(OSA), and weight loss has been shown to reduce disease severity. Objective: To …

Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022 - Wiley Online Library
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …