The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …

We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …

Background Gain-of-function mutations in STING1 underlie a type I interferonopathy termed
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …

Summary 2′, 3′-cGAMP, produced by the DNA sensor cGAS, activates stimulator of
interferon genes (STING) and triggers immune response during infection. Tremendous effort …

Objective Autoinflammatory type I interferonopathies, chronic atypical neutrophilic
dermatosis with lipodystrophy and elevated temperature/proteasome-associated …

The cGMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway plays a
critical role in sensing dsDNA localized to the cytosol, resulting in the activation of a robust …

STING-associated vasculopathy with onset in infancy (SAVI) is a type I interferonopathy
caused by gain-of-function mutations in STING1 encoding stimulator of interferon genes …

Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by
dysregulation in the innate immune system. The molecular mechanisms of these disorders …

In addition to susceptibility to infections, conventional primary immunodeficiency disorders
(PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as …