Metabolism is the complex network of chemical reactions occurring within every cell and
organism, maintaining life, mediating ecosystem processes and affecting Earth's climate …

Cell science has made significant progress by focusing on understanding individual cellular
processes through reductionist approaches. However, the sheer volume of knowledge …

This paper explores the use of applied mathematical modelling in the field of evolutionary
biochemistry. The authors demonstrate how mathematical models can be applied to better …

It is widely acknowledged that the construction of large-scale dynamic models in systems
biology requires complex modelling problems to be broken up into more manageable …

Antibiotic resistance poses mounting risks to human health, as current antibiotics are losing
efficacy against increasingly resistant pathogenic bacteria. Of particular concern is the …

Computational models have great potential to accelerate bioscience, bioengineering, and
medicine. However, it remains challenging to reproduce and reuse simulations, in part …

Tissue Forge is an open-source interactive environment for particle-based physics,
chemistry and biology modeling and simulation. Tissue Forge allows users to create …

Biochemical interactions in systems and synthetic biology are often modeled with chemical
reaction networks (CRNs). CRNs provide a principled modeling environment capable of …

Ocean metabolism constitutes a complex, multiscale ensemble of biochemical reaction
networks harbored within and between the boundaries of a myriad of organisms. Gaining a …

The elevation of Synthetic Biology from single cells to multicellular simulations would be a
significant scale-up. The spatiotemporal behavior of cellular populations has the potential to …