The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

The complement system, an essential part of the innate immune system, is composed of a
group of secreted and membrane proteins that collectively participate in maintaining the …

The complement system plays critical roles in development, homeostasis, and regeneration
in the central nervous system (CNS) throughout life; however, complement dysregulation in …

Background Inflammasome-mediated neuroinflammation plays an important role in the
pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The …

Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …

Traumatic brain injury (TBI) is the principal cause of death and disability in children and
young adults. Clinical and preclinical research efforts have been carried out to understand …