E1 enzymes as therapeutic targets in cancer
SH Barghout, AD Schimmer - Pharmacological reviews, 2021 - ASPET
Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
UFMylation: a ubiquitin-like modification
X Zhou, SJ Mahdizadeh, M Le Gallo… - Trends in Biochemical …, 2024 - cell.com
Post-translational modifications (PTMs) add a major degree of complexity to the proteome
and are essential controllers of protein homeostasis. Amongst the hundreds of PTMs …
and are essential controllers of protein homeostasis. Amongst the hundreds of PTMs …
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control
R Ishimura, S Ito, G Mao, S Komatsu-Hirota, T Inada… - Science …, 2023 - science.org
Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated with
intracellular proteins through ufmylation, similar to ubiquitylation. Ufmylation is involved in …
intracellular proteins through ufmylation, similar to ubiquitylation. Ufmylation is involved in …
The UFM1 system: Working principles, cellular functions, and pathophysiology
Summary Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation
JJ Peter, HM Magnussen, PA DaRosa, D Millrine… - The EMBO …, 2022 - embopress.org
Protein UFMylation, ie, post‐translational modification with ubiquitin‐fold modifier 1 (UFM1),
is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological …
is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological …
Decrypting UFMylation: how proteins are modified with UFM1
Besides ubiquitin (Ub), humans have a set of ubiquitin-like proteins (UBLs) that can also
covalently modify target proteins. To date, less is known about UBLs than Ub and even less …
covalently modify target proteins. To date, less is known about UBLs than Ub and even less …
Structural basis for UFM1 transfer from UBA5 to UFC1
Ufmylation is a post-translational modification essential for regulating key cellular processes.
A three-enzyme cascade involving E1, E2 and E3 is required for UFM1 attachment to target …
A three-enzyme cascade involving E1, E2 and E3 is required for UFM1 attachment to target …
The post-translational role of UFMylation in physiology and disease
X Wang, X Xu, Z Wang - Cells, 2023 - mdpi.com
Ubiquitin-fold modifier 1 (UFM1) is a newly identified ubiquitin-like protein that has been
conserved during the evolution of multicellular organisms. In a similar manner to ubiquitin …
conserved during the evolution of multicellular organisms. In a similar manner to ubiquitin …
Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays
Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in
development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated …
development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated …
Inhibition of UBA5 expression and induction of autophagy in breast cancer cells by usenamine A
Breast cancer is now the most common type of cancer worldwide, surpassing lung cancer.
This issue is further worsened by the lack of effective therapies for the disease. Recent …
This issue is further worsened by the lack of effective therapies for the disease. Recent …