Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …

The properties of dorsal root ganglia (DRG) neurons that innervate the distal colon are
poorly defined, hindering our understanding of their roles in normal physiology and …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

The ability to react to environmental change is crucial for the survival of an organism and an
essential prerequisite is the capacity to detect and respond to aversive stimuli. The …

Mechanosensitive ion channels are gated directly by physical stimuli and transduce these
stimuli into electrical signals. Several criteria must apply for a channel to be considered …

Extracellular acid can have important effects on neuron function. In central and peripheral
neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular …