Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …

Given the global increase in air pollution and its crucial role in human health, as well as the
steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the …

Marijuana is a widely used psychoactive substance in the US and medical and recreational
legalization has risen over the past decade. Despite the growing number of individuals …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Characterizing influences of DNA methylation (DNAm) on non-coding RNAs (ncRNAs) is
important to understand the mechanisms of gene regulation and cancer outcome. In our …

Microarray technology has been used to measure genome-wide DNA methylation in
thousands of individuals. These studies typically test the associations between individual …

Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …

Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …

Although toxicology uses animal models to represent real-world human health scenarios, a
critical translational gap between laboratory-based studies and epidemiology remains. In …

Abstract Background The Infinium EPIC array measures the methylation status of> 850,000
CpG sites. The EPIC BeadChip uses a two-array design: Infinium Type I and Type II probes …