The metastatic process, ie the dissemination of cancer cells throughout the body to seed
secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to …

Since its discovery in the early 1990's, cortactin has emerged as a key signaling protein in
many cellular processes, including cell adhesion, migration, endocytosis, and tumor …

Integrin signaling critically contributes to the progression, growth, and therapy resistance of
malignant tumors. Here, we show that targeting of β1 integrins with inhibitory antibodies …

Branched actin assembly is critical for a variety of cellular processes that underlie cell
motility and invasion, including cellular protrusion formation and membrane trafficking …

Weaver, 2008). Cortactin was first identified as a prominent substrate of the Src nonreceptor
tyrosine kinase. Its name was derived from the observation that cortactin localizes to cortical …

Cortactin is a cytoskeletal protein and src kinase substrate that is frequently overexpressed
in cancer. Animal studies suggest that cortactin overexpression increases tumor …

Invadopodia are actin-dependent organelles that function in the invasion and remodeling of
the extracellular matrix (ECM) by tumor cells. Cortactin, a regulator of the Arp2/3 complex, is …

Invasive cancer cells form dynamic adhesive structures associated with matrix degradation
called invadopodia. Calpain 2 is a calcium-dependent intracellular protease that regulates …

Invadopodia are proteolytically active protrusions formed by invasive tumoral cells when
grown on an extracellular matrix (ECM) substratum. Although many molecular components …

Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells
enriched in proteins that regulate actin polymerization. The on–off regulatory switch that …