The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …

Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …

Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

The formation of C–N bonds—of great importance to the pharmaceutical industry—can be
facilitated enzymatically using nucleophilic and nitrene transfer mechanisms. However …

Fast screening of enzyme variants is crucial for tailoring biocatalysts for the asymmetric
synthesis of non-natural chiral chemicals, such as amines. However, most existing …

Despite the increasing use of biocatalysis for organic synthesis, there are currently no
databases that adequately capture synthetic biotransformations. The lack of a biocatalysis …

The synthesis of structurally diverse amines is of fundamental significance in the
pharmaceutical industry due to the ubiquitous presence of amine motifs in biologically active …

Biocatalysis is a promising approach to sustainably synthesize pharmaceuticals, complex
natural products, and commodity chemicals at scale. However, the adoption of biocatalysis …

Enzymatic reductive amination, being a direct, selective and green methodology, has
attracted significant interest in a short period of time and is emerging as a powerful tool for …