Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …

The present review aims to summarize the pharmacological profile of 1, 2, 4-triazole, one of
the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant …

Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces
some carbon atoms in the ring of naphthalene. Its molecular formula is C 8 H 6 N 2, formed …

Quinoxaline, a fused heterocycle of benzene and pyrazine rings has gained considerable
attention in the field of contemporary medicinal chemistry. The moiety is of substantial …

Abstract Tumor Necrosis Factor Alpha (TNF-α) is a pleiotropic pro-inflammatory cytokine. It
act as central biological regulator in critical immune functions, but its dysregulation has been …

Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …

In our present study, four new, designated as murrayakonine A–D (1–4), along with 18
known carbazole alkaloids were isolated from CHCl3: MeOH (1: 1) crude extracts of the …

Abstract A new series of 3-[2-(5-mercapto-4-phenyl-4H-1, 2, 4-traiazol-3-yl) ethyl] quinoxalin-
2 (1H)-one (5a-v) derivatives was synthesized and subjected to in vitro evaluation for anti …

Background Chronic inflammatory diseases are major causes of global morbidity and
mortality. Acute inflammation is meant to protect the body against foreign agents, but it also …

Cutaneous melanoma is one of the most aggressive human cancers and is the deadliest
form of skin cancer, essentially due to metastases. Novel therapies are always required …