The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is
present in a large number of biologically active molecules, including several drugs currently …

Abstract P2X7R, which is a member of the purinergic P2 receptor family, is widely expressed
in many immune cells, such as macrophages, lymphocytes, monocytes, and neutrophils …

(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range
of biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and …

Sepsis-associated acute kidney injury (AKI) is a serious clinical problem, without effective
drugs. Abnormal activation of the purinergic P2X7 receptor (P2X7R) in septic kidneys makes …

Abstract The P2X7 receptor (P2X7R) is an ATP-gated ion channel and potential therapeutic
target for new drug development. In this study, we synthesized a series of new 1, 4 …

Juglone is a metabolite produced by several species of plants, in particular Juglans nigra.
Additionally, juglone is a 1, 4-naphthoquinone that has several biological actions …

The purinergic P2X7 receptor (P2X7R), an ATP-gated non-selective cation channel, has
emerged as a gatekeeper of inflammation that controls the release of proinflammatory …

P2X7 receptor promotes inflammatory response and neuropathic pain. New drugs capable
of impairing inflammation and pain-reducing adverse effects extracted from plant extracts …

P2X7 receptors (P2X7Rs) are ligand-gated ion channels that play a significant role in
inflammation and are considered a potential therapeutic target for some inflammatory …

A copper‐catalyzed cyclization reaction of 2‐(3‐arylpropioloyl) benzaldehydes was
developed, leading to benzylated 1, 4‐naphthoquinones via radical‐triggered cascade …