In this position paper, we discuss two relevant topics:(i) generic multiscale computing on
emerging exascale high-performing computing environments, and (ii) the scaling of such …

We expect that multiscale simulations will be one of the main high performance computing
workloads in the exascale era. We propose multiscale computing patterns as a generic …

Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …

Background: Data management is an important, complex and multidimensional process in
clinical trials. The execution of this process is very difficult and expensive without the use of …

As virtualization technologies mature and become ever more widespread, cloud computing
has emerged as a promising paradigm for e-science. In order to facilitate successful …

The challenge of modelling cancer presents a major opportunity to improve our ability to
reduce mortality from malignant neoplasms, improve treatments and meet the demands …

The management of certain systems, such as manufacturing facilities, supply chains, or
communication networks implies assessing the consequences of decisions, aimed for the …

Despite the promises made that genomic sequencing would transform therapy by
introducing a new era of personalized medicine, relatively few tangible breakthroughs have …

This article presents the results of a study aimed at a developing an approach to the design
of information infrastructure of medical institutions that use knowledge-based clinical …

Genomics has made enormous progress in the twelve years since the publication of the first
draft human genome sequence, but it has not yet been translated into the clinic. Despite …