A Mammalian Cell's Guide on How to Process a Bacteriophage

L Kan, JJ Barr - Annual Review of Virology, 2023 - annualreviews.org
Bacteriophages are enigmatic entities that defy definition. Classically, they are specialist
viruses that exclusively parasitize bacterial hosts. Yet this definition becomes limiting when …

Carbon-negative synthetic biology: challenges and emerging trends of cyanobacterial technology

C Tan, P Xu, F Tao - Trends in biotechnology, 2022 - cell.com
Global warming and climate instability have spurred interest in using renewable carbon
resources for the sustainable production of chemicals. Cyanobacteria are ideal cellular …

Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo

EA Ashworth, RCT Wright, RK Shears… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease
including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health …

[HTML][HTML] Multi-layered genome defences in bacteria

A Agapov, KS Baker, P Bedekar, RP Bhatia… - Current Opinion in …, 2024 - Elsevier
Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic
elements, including restriction-modification systems and CRISPR–Cas. In recent years …

Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?

KM Ling, SM Stick, A Kicic - Frontiers in Medicine, 2023 - frontiersin.org
For those born with cystic fibrosis (CF), hyper-concentrated mucus with a dysfunctional
structure significantly impacts CF airways, providing a perfect environment for bacterial …

Relevance of the bacteriophage adherence to mucus model for Pseudomonas aeruginosa phages

GMF Almeida, J Ravantti, N Grdzelishvili… - Microbiology …, 2024 - journals.asm.org
Pseudomonas aeruginosa infections are getting increasingly serious as antimicrobial
resistance spreads. Phage therapy may be a solution to the problem, especially if improved …

Analysis of genetic structure and function of clustered regularly interspaced short palindromic repeats loci in 110 Enterococcus strains

S Tao, D Zhou, H Chen, N Li, L Zheng, Y Fang… - Frontiers in …, 2023 - frontiersin.org
Clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-
associated proteins (Cas) are an adaptive immune system involved in specific defenses …

Molecular studies of phages-Klebsiella pneumoniae in mucoid environment: innovative use of mucolytic agents prior to the administration of lytic phages

O Pacios, L Blasco, C Ortiz Cartagena, I Bleriot… - Frontiers in …, 2023 - frontiersin.org
Mucins are important glycoproteins that form a protective layer throughout the
gastrointestinal and respiratory tracts. There is scientific evidence of increase in phage …

[HTML][HTML] Unveiling Hidden Allies: In Silico Discovery of Prophages in Tenacibaculum Species

C Ramírez, J Romero - Antibiotics, 2024 - mdpi.com
Tenacibaculosis, caused by Tenacibaculum species, is a significant disease in aquaculture,
leading to high mortality and economic losses. Antibiotic treatment raises concerns about …

Mucosal Environment Induces Phage Susceptibility in Streptococcus mutans

LR Sundberg, N Rantanen… - Therapy, Applications …, 2022 - liebertpub.com
Pathogenic bacteria are attracted toward mucosa, as it is their way of entry into the body.
However, we know surprisingly little about the phage-bacterium interactions in the mucosal …