Epilepsy is a group of enduring neurological disorder characterized by spontaneous and
recurrent seizures with heterogeneous etiology, clinical expression, severity, and prognosis …

Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to
mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a …

The causative link between focal cortical malformations (FCMs) and epilepsy is well
accepted, especially among patients with focal cortical dysplasia type II (FCDII) and …

The blood–brain barrier (BBB) is a physiological barrier maintaining a specialized brain
micromilieu that is necessary for proper neuronal function. Endothelial tight junctions and …

Objective Tuberous sclerosis complex (TSC) is a genetic disorder, characterized by tumor
formation in the brain and other organs, and severe neurological symptoms, such as …

Objective Genetic variations in proteins of the mechanistic target of rapamycin (mTOR)
pathway cause a spectrum of neurodevelopmental disorders often associated with brain …

Our understanding of the etiological mechanisms leading up to epilepsy has undergone
radical changes over time due to more insights into the complexity of the disease. The …

In utero electroporation (IUE) is a technique developed in the early 2000s to transfect the
neurons and neural progenitors of embryonic brains, thus enabling continued development …

Epilepsy accounts for a significant proportion of the burden of neurological disorders.
Neuroinflammation acting as the inflammatory response to epileptic seizures is …

Hyperactivation of the mechanistic target of rapamycin (mTOR) signaling pathway is linked
to more than a dozen neurologic diseases, causing a range of pathologies, including excess …