Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …

Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

The MET tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and
angiogenesis, thereby acting as a powerful expedient for cancer dissemination. MET can …

Receptor tyrosine kinase (RTK) targeted agents such as trastuzumab, imatinib,
bevacizumab, and gefitinib inhibitors have illustrated the utility of targeting this protein class …

Metastasis follows the inappropriate activation of a genetic programme termed invasive
growth, which is a physiological process that occurs during embryonic development and …

Sarcomas are a rare and diverse group of tumours that are derived from connective tissues,
including bone, muscle and cartilage. Although there are instances of hereditary …

Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and
patient survival is poor in the presence of metastatic disease. Few determinants that regulate …

Patients presenting with metastatic rhabdomyosarcoma (RMS), the most common soft-tissue
sarcoma in children, have a very poor clinical prognosis. This is due, in large part, to our …

PDGF signaling regulates the development of mesenchymal cell types in the embryo and in
the adult, but the role of receptor activation in tissue homeostasis has not been investigated …