Recent progress in the electrochemical selenofunctionalization of alkenes and alkynes

P Qu, YQ Jiang, YH Wang, GQ Liu - Green Chemistry, 2023 - pubs.rsc.org
Organoselenium compounds, a significant class of substances with applications in the
biological, medicinal and material sciences as well as in modern organic synthesis, have …

New modalities for challenging targets in drug discovery

E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

A comprehensive review on biological activities of oxazole derivatives

S Kakkar, B Narasimhan - BMC chemistry, 2019 - Springer
The utility of oxazole as intermediates for the synthesis of new chemical entities in medicinal
chemistry have been increased in the past few years. Oxazole is an important heterocyclic …

Synthesis of CF3–Isoquinolinones and Imidazole-Fused CF3–Isoquinolinones Based on C–H Activation-Initiated Cascade Reactions of 2-Aryloxazolines

M Liang, S Yan, Y Xu, C Ma, X Zhang… - The Journal of Organic …, 2024 - ACS Publications
Presented herein are novel syntheses of CF3-isoquinolinones and imidazole fused CF3-
isoquinolinones based on the cascade reactions of 2-aryloxazolines with trifluoromethyl …

Site-selective modification of peptide backbones

A Boto, CC González, D Hernández… - Organic Chemistry …, 2021 - pubs.rsc.org
The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Isoxazole/Isoxazoline skeleton in the structural modification of natural products: a review

X Wang, Q Hu, H Tang, X Pan - Pharmaceuticals, 2023 - mdpi.com
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …

Catalytic Enantioselective Isocyanide‐Based Reactions: Beyond Passerini and Ugi Multicomponent Reactions

J Luo, GS Chen, SJ Chen, ZD Li… - Chemistry–A European …, 2021 - Wiley Online Library
The development of catalytic enantioselective isocyanide‐based reactions is currently of
great interest because the resulting products are valuable in organic synthesis …

Naturally occurring oxazole-containing peptides

JT Mhlongo, E Brasil, BG de la Torre, F Albericio - Marine drugs, 2020 - mdpi.com
Oxazole-containing peptides are mostly of marine origin and they form an intriguing family
with a broad range of biological activities. Here we classify these peptides on the basis of …

Recent advances on metal-free, visible-light-induced catalysis for assembling nitrogen-and oxygen-based heterocyclic scaffolds

R Pawlowski, F Stanek, M Stodulski - Molecules, 2019 - mdpi.com
Heterocycles are important class of structures, which occupy a major space in the domain of
natural and bioactive compounds. For this reason, development of new synthetic strategies …

Flow chemistry: towards a more sustainable heterocyclic synthesis

P Brandão, M Pineiro… - European Journal of …, 2019 - Wiley Online Library
Flow Chemistry is a revolutionary field in Organic Chemistry. By changing the conventional
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …