The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …

The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors related to their anatomical and pathophysiological differences from normal tissues …

Approximately 30% of human lung cancers acquire mutations in either Keap1 or Nfe2l2,
resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which controls oxidative …

Most solid tumors possess unique pathophysiological characteristics that are not observed
in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature …

In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …

Oxygen is the essential molecule for all aerobic organisms, and plays predominant role in
ATP generation, namely, oxidative phosphorylation. During this process, reactive oxygen …

Heat shock proteins (Hsps) have been studied for many years and there is now a large body
of evidence that demonstrates the role of Hsp upregulation in tissue and cell protection in a …

The discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its
functional role in the pathogenesis of a wide spectrum of biological and pathological …

Tumor and inflammation have many common features. One hallmark of both is enhanced
vascular permeability, which is mediated by various factors including bradykinin, nitric oxide …

Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …