Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs

ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

Mesenchymal stem cells and their microenvironment

J Liu, J Gao, Z Liang, C Gao, Q Niu, F Wu… - Stem Cell Research & …, 2022 - Springer
Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-
directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis …

TNF-α and IFN-γ participate in improving the immunoregulatory capacity of mesenchymal stem/stromal cells: Importance of cell–cell contact and extracellular vesicles

L López-García, ME Castro-Manrreza - International journal of molecular …, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) have an immunoregulatory capacity and have
been used in different clinical protocols requiring control of the immune response. However …

Immunomodulatory properties of mesenchymal stromal cells: an update

L Müller, A Tunger, M Wobus, M von Bonin… - Frontiers in cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are characterized by an extraordinary capacity to
modulate the phenotype and functional properties of various immune cells that play an …

Identifying the therapeutic significance of mesenchymal stem cells

VK Mishra, HH Shih, F Parveen, D Lenzen, E Ito… - Cells, 2020 - mdpi.com
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due
to their immense potential for immunosuppression and their therapeutic role in immune …

Mesenchymal stem cell therapy: hope for patients with systemic lupus erythematosus

A Li, F Guo, Q Pan, S Chen, J Chen, H Liu… - Frontiers in …, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Although previous
studies have demonstrated that SLE is related to the imbalance of cells in the immune …

Stem cells in veterinary medicine—current state and treatment options

M Voga, N Adamic, M Vengust… - Frontiers in veterinary …, 2020 - frontiersin.org
Regenerative medicine is a branch of medicine that develops methods to grow, repair, or
replace damaged or diseased cells, organs or tissues. It has gained significant momentum …

Current understanding of the immunosuppressive properties of mesenchymal stromal cells

LL de Castro, M Lopes-Pacheco, DJ Weiss… - Journal of Molecular …, 2019 - Springer
Several studies have demonstrated the anti-inflammatory potential of mesenchymal stromal
cells (MSCs) isolated from bone marrow, adipose tissue, placenta, and other sources …

The immunomodulatory effects of mesenchymal stem cells on regulatory B cells

J Liu, Q Liu, X Chen - Frontiers in Immunology, 2020 - frontiersin.org
The therapeutic potential of mesenchymal stem cells (MSCs) has been investigated in many
preclinical and clinical studies. This potential is dominantly based on the …

Immunomodulatory effect of MSC on B cells is independent of secreted extracellular vesicles

L Carreras-Planella, M Monguió-Tortajada… - Frontiers in …, 2019 - frontiersin.org
Mesenchymal stem or stromal cells (MSC) have proven immunomodulatory properties
toward B cell activation and induce regulatory B cells (Breg), through a dual mechanism of …