Antibiotic drug–target interactions, and their respective direct effects, are generally well
characterized. By contrast, the bacterial responses to antibiotic drug treatments that …

Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional
centers within the bacterial ribosome to impact all four principle stages (initiation, elongation …

VOL. 54, 1965 GENETICS: CR WOESE 1547 called an" a X b X c code," predicted on
theoretical grounds some timeago. 1'2 At the time that this theoretical code was proposed, it …

The fidelity of biological information flow is critical. Deoxyribonucleic acid (DNA) replication,
with its attendant proofreading and repair processes, has an error level in the range of 10-8 …

Cystic fibrosis (CF) is caused by mutations in the gene encoding the CF transmembrane
conductance regulator (CFTR). A single recessive mutation, the deletion of phenylalanine …

▪ Abstract Modern chemotherapy has played a major role in our control of tuberculosis. Yet
tuberculosis still remains a leading infectious disease worldwide, largely owing to …

Antibiotic therapy is the routine method for treating bacterial infections and has saved
hundreds of millions of lives over the last century. However, low bioavailability, side effects …

The faithful and rapid translation of genetic information into peptide sequences is an
indispensable property of the ribosome. The mechanistic understanding of strategies used …

Aminoglycosides are widely used antibiotics that cause messenger RNA decoding errors,
block mRNA and transfer RNA translocation, and inhibit ribosome recycling. Ribosome …