[HTML][HTML] Integrated physiology and systems biology of PPARα
S Kersten - Molecular metabolism, 2014 - Elsevier
Abstract The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription
factor that plays a major role in metabolic regulation. This review addresses the functional …
factor that plays a major role in metabolic regulation. This review addresses the functional …
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
H Guillou, D Zadravec, PGP Martin… - Progress in lipid research, 2010 - Elsevier
In mammalian cells, elongases and desaturases play critical roles in regulating the length
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In …
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In …
Peroxisome proliferator‐activated receptor alpha target genes
The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …
transcription factor involved in the regulation of a variety of processes, ranging from …
[HTML][HTML] Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial
H Bjermo, D Iggman, J Kullberg, I Dahlman… - The American journal of …, 2012 - Elsevier
Background: Replacing SFAs with vegetable PUFAs has cardiometabolic benefits, but the
effects on liver fat are unknown. Increased dietary n-6 PUFAs have, however, also been …
effects on liver fat are unknown. Increased dietary n-6 PUFAs have, however, also been …
[HTML][HTML] Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults
Background Per-and polyfluoroalkyl substances (PFASs) exposure is ubiquitous among the
US population and has been linked to adverse health outcomes including cardiometabolic …
US population and has been linked to adverse health outcomes including cardiometabolic …
Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …
Peroxisome proliferator-activated receptor α target genes
Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the
superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic …
superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic …
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
K Takeuchi, K Reue - American Journal of Physiology …, 2009 - journals.physiology.org
Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have
important roles in metabolic homeostasis. The molecular identification of genes encoding …
important roles in metabolic homeostasis. The molecular identification of genes encoding …
Visualising associations between paired 'omics' data sets
Background Each omics platform is now able to generate a large amount of data. Genomics,
proteomics, metabolomics, interactomics are compiled at an ever increasing pace and now …
proteomics, metabolomics, interactomics are compiled at an ever increasing pace and now …
[HTML][HTML] PPAR-α as a key nutritional and environmental sensor for metabolic adaptation
Peroxisome proliferator-activated receptors (PPARs) are transcription factors that belong to
the superfamily of nuclear hormone receptors and regulate the expression of several genes …
the superfamily of nuclear hormone receptors and regulate the expression of several genes …