DNA-damaging agents and endogenous DNA damage constantly harm genome integrity.
Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in …

The key DNA repair enzyme DNA-PKcs has several and important cellular functions. Loss of
DNA-PKcs activity in mice has revealed essential roles in immune and nervous systems. In …

Developing B and T lymphocytes requires programmed DNA double-strand breaks followed
by the activation of the DNA damage response (DDR) pathway and DNA repair. It is …

B lymphocyte development has two DNA recombination processes: V (D) J recombination of
the immunoglobulin (Igh) gene variable region, and class switching of the Igh constant …

Understanding the interplay between genetic drift, natural selection, gene flow, and
demographic history in driving phenotypic and genomic differentiation of insular populations …

Background Triple‐negative breast cancer (TNBC) presents the most challenging subtype of
all breast cancers because of its aggressive clinical phenotypes and absence of viable …

Objective The DNA double-strand break (DSB) repair system plays a key role in eliminating
DNA damage in hematopoietic cells caused by benzene, toluene, ethylbenzene, and xylene …

Methamphetamine (METH) abuse remains a global health concern, with emerging evidence
highlighting its genotoxic potential. In the central nervous system METH enters …

B lymphocyte development has two DNA recombination processes: V (D) J recombination of
the immunoglobulin (Igh) gene variable region and class switching of the Igh constant …

B lymphocyte development includes two DNA recombination processes, the V (D) J
recombination of immunoglobulin (Igh) gene variable region and class switching when the …