Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …

Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …

In 1889, Dr. Stephen Paget proposed the “seed and soil” hypothesis, which states that
cancer cells (the seeds) need the proper microenvironment (the soil) for them to grow …

Pulmonary hypertension (PH) is an unremitting disease defined by a progressive increase in
pulmonary vascular resistance leading to right-sided heart failure. Using mice with genetic …

In muscle tissue the protein caveolin-3 forms caveolae–flask-shaped invaginations localized
on the cytoplasmic surface of the sarcolemmal membrane. Caveolae have a key role in the …

Rationale: Pulmonary arterial hypertension is characterized by endothelial dysfunction,
impaired bone morphogenetic protein receptor 2 (BMPR2) signaling, and increased …

Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher
Ca2+ levels in pulmonary hypertension (PH). Whether the functional properties and …

Abstract Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by
progressive fibrosis of skin and multiple internal organs and severe functional and structural …

Objective Recent studies have implicated caveolin 1 in the regulation of transforming growth
factor β (TGFβ) downstream signaling. Given the crucial role of TGFβ in the pathogenesis of …

It is becoming increasingly apparent that the tumor micro-environment plays a critical role in
human breast cancer onset and progression. Therefore, we isolated cancer-associated …