[HTML][HTML] Beyond its psychiatric use: the benefits of low-dose lithium supplementation

SI Hamstra, BD Roy, P Tiidus, AJ MacNeil… - Current …, 2023 - ncbi.nlm.nih.gov
Lithium is most well-known for its mood-stabilizing effects in the treatment of bipolar
disorder. Due to its narrow therapeutic window (0.5-1.2 mM serum concentration), there is a …

[HTML][HTML] The role of serine/threonine protein kinases in cardiovascular disease and potential therapeutic methods

Y Wu, Y Zou, C Song, K Cao, K Cai, S Chen… - Biomedicine & …, 2024 - Elsevier
Protein phosphorylation is an important link in a variety of signaling pathways, and most of
the important life processes in cells involve protein phosphorylation. Based on the amino …

Low-dose lithium supplementation promotes adipose tissue browning and sarco (endo) plasmic reticulum Ca2+ ATPase uncoupling in muscle

MS Geromella, CR Ryan, JL Braun, MS Finch… - Journal of Biological …, 2022 - ASBMB
Sarco (endo) plasmic reticulum Ca 2+-ATPase (SERCA) uncoupling in skeletal muscle and
mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige adipose tissue …

Cardiovascular effects of bufotenin on human 5-HT4 serotonin receptors in cardiac preparations of transgenic mice and in human atrial preparations

J Neumann, N Schulz, C Fehse, K Azatsian… - Naunyn-Schmiedeberg's …, 2023 - Springer
It is unclear whether bufotenin (= N, N-dimethyl-serotonin= 5-hydroxy-N, N-dimethyl-
tryptamine), a hallucinogenic drug, can act on human cardiac serotonin 5-HT4 receptors …

[HTML][HTML] Methamphetamine increases force of contraction in isolated human atrial preparations through the release of noradrenaline

J Neumann, W Hußler, K Azatsian, B Hofmann… - Toxicology Letters, 2023 - Elsevier
We measured the cardiac contractile effects of the sympathomimetic amphetamine-like drug
methamphetamine alone and in the presence of cocaine or propranolol in human atrial …

Levosimendan increases the phosphorylation state of phospholamban in the isolated human atrium

LMR Abella, R Hoffmann, J Neumann… - Naunyn-Schmiedeberg's …, 2023 - Springer
Levosimendan (up to 10 µM) given alone failed to increase force of contraction in isolated
electrically stimulated (1 Hz) left atrial (LA) preparations from wild-type mice. Only in the …

[HTML][HTML] Cardiovascular effects of metoclopramide and domperidone on human 5-HT4-serotonin-receptors in transgenic mice and in human atrial preparations

J Neumann, T Seidler, C Fehse, M Marušáková… - European journal of …, 2021 - Elsevier
It is unclear whether metoclopramide and domperidone act on human cardiac serotonin 5-
HT 4-receptors. Therefore, we studied transgenic mice that only express the human 5-HT 4 …

Insights into the post-translational modifications in heart failure

X Zhang, Y Wang, H Li, DW Wang, C Chen - Ageing Research Reviews, 2024 - Elsevier
Heart failure (HF), as the terminal manifestation of multiple cardiovascular diseases, causes
a huge socioeconomic burden worldwide. Despite the advances in drugs and medical …

Protective role of triiodothyronine in sepsis‑induced cardiomyopathy through phospholamban downregulation

Q Xie, Q Yi, J Zhu, B Tan, H Xiang… - International …, 2025 - spandidos-publications.com
Sepsis is often a cause of mortality in patients admitted to the intensive care unit. Notably,
the heart is the organ most susceptible to the impact of sepsis and this condition is referred …

Effects of hallucinogenic drugs on the human heart

J Neumann, S Dhein, U Kirchhefer… - Frontiers in …, 2024 - frontiersin.org
Hallucinogenic drugs are used because they have effects on the central nervous system.
Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5 …