The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …

Disclosures: Dr. Narazaki reported grants from JSPS KAKENHI and grants from Chugai
Pharmaceutical Co., Ltd. during the conduct of the study; personal fees from Mitsubishi …

Background Diffuse large B-cell lymphomas (DLBCLs) are phenotypically and genetically
heterogeneous. Gene-expression profiling has identified subgroups of DLBCL (activated B …

With ageing, normal human tissues experience an expansion of somatic clones that carry
cancer mutations,,,,,–. However, whether such clonal expansion exists in the non-neoplastic …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue
injuries, contributes to host defense through the stimulation of acute phase responses …

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair
and is associated with an increased risk of cancer,–. However, how such cycles affect the …

Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

Studies that bridge innate immunity and various diseases are making rapid advances.
Macrophages and dendritic cells play a leading role in innate immunity, using pattern …