The release of the inherent ring strain of cyclobutane and cyclopropane derivatives allows a
rapid build-up of molecular complexity. This review highlights the state-of-the-art of the ring …

This review summarizes the progress in the fluorination and fluoroalkylation of electron‐rich
systems with diverse fluorine (F) and fluoroalkyl (Rfn) reagents employing hypervalent …

Short aliphatic groups are prevalent in bioactive small molecules and play an essential role
in regulating physicochemistry and molecular recognition phenomena. Delineating their …

This review will cover the importance of and most recent approaches toward geminal
difluoroalkyl groups. Transition metal-mediated, photochemical, organocatalytic, and other …

A main‐group catalysis‐based strategy to access 8‐membered carbocycles via the direct
carbofunctionalization of 2‐phenethyl‐substituted 1, 3‐dienes is disclosed. Through the …

Cyclic β, β‐difluoro‐carbonyl compounds have a venerable history as drug discovery leads,
but limitations in the synthesis arsenal continue to impede chemical space exploration. This …

Herein, we report a new strategy for carbon− carbon bond scission and intramolecular ring
expansion fluorination of unactivated cyclopropanes, which was accomplished with a new …

Saturated, fluorinated carbocycles are emerging as important modules for contemporary
drug discovery. To expand the current portfolio, the synthesis of novel trifluorinated tetralins …

A highly diastereoselective [3+ 2] cycloaddition of aziridines with difluorinated silyl enol
ethers has been developed. This approach provides a facile methodology for highly …

A new efficient formal [2+ 3] cyclization of p-hydroxybenzyl alcohols with
difluoroenoxysilanes has been established. This convenient one-pot sequential procedure …