For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

Vitamin B12 is assimilated and transported by complex mechanisms that involve three
transport proteins, intrinsic factor (IF), haptocorrin (HC) and transcobalamin (TC) and their …

Abstract Vitamin B12 (B12; also known as cobalamin) is a cofactor in many metabolic
processes; deficiency of this vitamin is associated with megaloblastic anaemia and various …

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …

Albumin is the most abundant plasmaprotein serving multiple functions as a carrier of
metabolites, hormones, vitamins, and drugs, as an acid/base buffer, as antioxidant and by …

Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal
tubule. This process involves two interacting receptors, megalin and cubilin, which form a …

Cobalamin (vitamin B12) deficiency is particularly common in the elderly (> 65 years of age),
but is often unrecognized because of its subtle clinical manifestations; although they can be …