Genetic and genomic mechanisms of primary aldosteronism

FL Fernandes-Rosa, S Boulkroun… - Trends in Molecular …, 2020 - cell.com
Aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia are the main
cause of primary aldosteronism (PA), the most frequent form of secondary hypertension …

Vascular and hormonal interactions in the adrenal gland

AB Abdellatif, FL Fernandes-Rosa… - Frontiers in …, 2022 - frontiersin.org
Primary aldosteronism is the most common form of secondary arterial hypertension, due to
excessive aldosterone production from the adrenal gland. Although somatic mutations have …

A murine model of increased coronary sinus pressure induces myocardial edema with cardiac lymphatic dilation and fibrosis

NR Nielsen, KV Rangarajan, L Mao… - American Journal …, 2020 - journals.physiology.org
Myocardial edema is a consequence of many cardiovascular stressors, including myocardial
infarction, cardiac bypass surgery, and hypertension. The aim of this study was to establish a …

Transcriptomics, epigenetics, and metabolomics of primary aldosteronism

A Spyroglou, GP Piaditis, G Kaltsas, KI Alexandraki - Cancers, 2021 - mdpi.com
Simple Summary Improvement in the understanding of the development of primary
aldosteronism, the most common cause of endocrine hypertension and mainly caused by …

A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence

M Surakhy, M Wallace, E Bond, LF Grochola… - British journal of …, 2020 - nature.com
Background Genome-wide association studies (GWASs) have enriched the fields of
genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a …

Primary aldosteronism: Pathophysiological mechanisms of cell death and proliferation

M Tetti, S Gong, F Veglio, M Reincke… - Frontiers in …, 2022 - frontiersin.org
Primary aldosteronism is the most common surgically curable form of hypertension. The
sporadic forms of the disorder are usually caused by aldosterone overproduction from a …

Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues

F Pecori Giraldi, A Sesta, L Tapella, MF Cassarino… - Scientific Reports, 2021 - nature.com
Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials
revealed therapeutic potential of both all-trans and 9-cis retinoic acid in patients with cortisol …

醛固酮产生腺瘤中细胞死亡和增殖机制

高寅洁, 童安莉 - 基础医学与临床, 2024 - journal11.magtechjournal.com
醛固酮产生腺瘤(APA) 是原发性醛固酮增多症(PA) 的主要病因之一, 目前对于其自主分泌醛固酮
机制的研究主要集中于体细胞驱动基因突变的筛查. 然而, 在APA 中, 肾上腺皮质细胞的死亡和 …

Primary Aldosteronism

S Boulkroun, MC Zennaro - Hydro Saline Metabolism: Epidemiology …, 2023 - Springer
Primary aldosteronism is the most common form of secondary hypertension. The two main
causes are aldosterone producing adenoma (APA) and bilateral adrenal hyperplasia. Over …

[PDF][PDF] Molecular and cellular mechanisms in the pathophysiology of primary aldosteronism

S Gong - 2023 - edoc.ub.uni-muenchen.de
AngII Angiotensin II APA aldosterone-producing adenoma APDH aldosterone-producing
diffuse hyperplasia APMs aldosterone-producing micronodules APN aldosterone-producing …