Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …

In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose
tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes …

Environmental cues profoundly affect cellular plasticity in multicellular organisms. For
instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and …

The role of tryptophan-kynurenine metabolism in psychiatric disease is well established, but
remains less explored in peripheral tissues. Exercise training activates kynurenine …

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …

Global rates of obesity continue to rise and are necessarily the consequence of a long-term
imbalance between energy intake and energy expenditure. This is the result of an …

An immune response must be tightly controlled so that it will be commensurate with the level
of response needed to protect the organism without damaging normal tissue. The roles of …

Extracellular purinergic molecules act as signaling molecules that bind to cellular receptors
and regulate signaling pathways. Growing evidence suggests that purines regulate …