Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
PT Nelson, DW Dickson, JQ Trojanowski, CR Jack… - Brain, 2019 - academic.oup.com
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
[HTML][HTML] Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
We review the literature on Tau and TDP-43 proteinopathies in aged human brains and the
relevant underlying pathogenetic cascades. Complex interacting pathways are implicated in …
relevant underlying pathogenetic cascades. Complex interacting pathways are implicated in …
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
Genome-wide association studies (GWAS) have identified> 80 Alzheimer's disease and
related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in …
related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in …
Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis
R Nicks, NF Clement, VE Alvarez, Y Tripodis… - Acta …, 2023 - Springer
Hippocampal sclerosis (HS) is associated with advanced age as well as transactive
response DNA-binding protein with 43 kDa (TDP-43) deposits. Both hippocampal sclerosis …
response DNA-binding protein with 43 kDa (TDP-43) deposits. Both hippocampal sclerosis …
rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues
Y Hu, J Sun, Y Zhang, H Zhang, S Gao, T Wang, Z Han… - BMC medicine, 2021 - Springer
Background It has been well established that the TMEM106B gene rs1990622 variant was a
frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the …
frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the …
The revised National Alzheimer's Coordinating Center's Neuropathology Form—available data and new analyses
Neuropathologic evaluation remains the gold standard for determining the presence and
severity of aging-related neurodegenerative diseases. Researchers at US Alzheimer's …
severity of aging-related neurodegenerative diseases. Researchers at US Alzheimer's …
From basic research to the clinic: innovative therapies for ALS and FTD in the pipeline
Amyotrophic lateral sclerosis (ALS) and Frontotemporal Degeneration (FTD) are
neurodegenerative disorders, related by deterioration of motor and cognitive functions and …
neurodegenerative disorders, related by deterioration of motor and cognitive functions and …
LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry
Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-
third of older individuals and is associated with cognitive impairment. However, there is a …
third of older individuals and is associated with cognitive impairment. However, there is a …
LATE‐NC in Alzheimer's disease: Molecular aspects and synergies
Alzheimer's disease (AD) is classically characterized by senile plaques and neurofibrillary
tangles (NFTs). However, multiple copathologies can be observed in the AD brain and …
tangles (NFTs). However, multiple copathologies can be observed in the AD brain and …
[HTML][HTML] The unique neuropathological vulnerability of the human brain to aging
I Ferrer - Ageing Research Reviews, 2023 - Elsevier
Abstract Alzheimer's disease (AD)-related neurofibrillary tangles (NFT), argyrophilic grain
disease (AGD), aging-related tau astrogliopathy (ARTAG), limbic predominant TDP-43 …
disease (AGD), aging-related tau astrogliopathy (ARTAG), limbic predominant TDP-43 …