The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

During brain ontogenesis, the temporal and spatial generation of the different types of
neuronal and glial cells from precursors occurs as a sequence of successive progenitor …

Benzodiazepines (BZ) modulate neurotransmitter-evoked chloride currents at the gamma-
aminobutyric acid type A (GABAA) receptor, the major inhibitory ion channel in the …

The sensitivity to GABA of Purkinje cells in thin cerebellar slices was examined by recording
either spontaneous inhibitory synaptic currents or ionic currents elicited by local GABA …

This article summarizes the development of cellular neuropharmacology and
neurotoxicology, based primarily on my own research. The progress of this field depends at …

Purified preparations of the inhibitory glycine receptor (GlyR) contain alpha and beta
subunits, which share homologous primary structures and a common transmembrane …

GABA is the main inhibitory neurotransmitter in the mammalian brain. The postsynaptic
GABAA receptor/pore complex is presumed to be a pentamer typically composed of a …

THE predominant inhibitory neurotrasmitter of the brain, GABA (γ-amino butyric acid),
activates chloride-selective ion pores integral to the receptor complex. Subunits comprising …

Abstract γ-Aminobutyric acid (GABA) is both a major inhibitory neurotransmitter in the CNS
and a product of β cells of the peripheral islets. Our previous studies, and those of others …

Different combinations of cloned rat brain subunit isoforms of the GABAA receptor channel
were expressed in Xenopus oocytes. The voltage-clamp technique was then used to …