For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

The generation of large numbers of functional human hepatocytes for cell-based
approaches to liver disease is an important and unmet goal. Direct reprogramming of …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

Obtaining fully functional cell types is a major challenge for drug discovery and regenerative
medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we …

Abstract Type 2 Diabetes Mellitus has reached epidemic proportions as a result of over-
nutrition and increasingly sedentary lifestyles. Current therapies, although effective, are not …

Liver disease is an important clinical problem, impacting over 30 million Americans and over
600 million people worldwide. It is the 12th leading cause of death in the United States and …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at
therapeutic doses but can cause severe liver injury and even liver failure after overdoses …

Cell-based therapies hold the potential to alleviate the growing burden of liver diseases.
Such therapies require human hepatocytes, which, within the stromal context of the liver, are …

Landfill leachate is a complex mixture characterized by high toxicity and able to contaminate
soils and waters surrounding the dumpsite, especially in developing countries where …