Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

The ability of bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2) to inhibit bone
resorption has been known since the 1960s, but it is only recently that a detailed molecular …

A direct synthesis of carbaldehydes through intramolecular dehydrogenative
aminooxygenation has been developed. The process uses a catalytic amount of copper (II) …

The imidazo [1, 2-a] pyridine scaffold is recognized as a privileged structure as it represents
a promising area for identification of lead structures towards the discovery of new synthetic …

Imidazo [1, 2-a] pyridine has been shown to be an important biologically active moiety. This
review is a compilation of the scattered output of results of the anticancer activities of the …

This review surveys recent developments (reported in the last fifteen years) in
organometallic‐chemistry‐based methods for the functionalization of imidazo [1, 2‐a] …

Protein prenylation is a post-translational modification controlling the localization, activity,
and protein–protein interactions of small GTPases, including the Ras superfamily. This …

Mapping the functionality of GTPases through small molecule inhibitors represents an
underexplored area in large part due to the lack of suitable compounds. Here we report on …