In the last decades, the understanding of the complex biological mechanisms that regulate
the life and growth of single cells and their reciprocal interaction has steadily increased. In …

Tissue mechanobiology is an emerging field with the overarching goal of understanding the
interplay between biophysical and biochemical responses affecting development …

Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in
cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit …

The extracellular matrix (ECM) of tissues is an important mediator of cell function. Moreover,
understanding cellular dynamics within their specific tissue context is also important for …

We demonstrate a label-free, scan-free intensity diffraction tomography technique utilizing
annular illumination (aIDT) to rapidly characterize large-volume three-dimensional (3-D) …

Efforts to mitigate the COVID-19 crisis revealed that fast, accurate, and scalable testing is
crucial for curbing the current impact and that of future pandemics. We propose an optical …

Metastasis is a leading cause of cancer‐related death and consists of a sequence of events
including tumor expansion, intravasation of cancer cells into the circulation, survival in the …

Local tissue mechanics play a critical role in cell function, but measuring these properties at
cellular length scales in living 3D tissues can present considerable challenges. Here we …

The mechanics of the extracellular matrix (ECM) have long been known to have important
implications for cancer metastasis and cell migration. An atypical increase in tumor ECM …

Metastatic melanoma is a complex and deadly disease. Due to its complexity, the
development of novel therapeutic strategies to inhibit metastatic melanoma remains an …